"To date, we have chosen not to make any public statement regarding our discussions with the US Department of Justice (DOJ). Our commitment to confidentiality is not only regarded as best practice in the UK but is also intended to respect the DOJ's commitment to confidentiality, as set out in its own rules as they apply to discussions with potential witnesses," the statement read.
"However, in view of misleading media briefings, we owe it to our client to issue this clarifying statement."
The statement continued: "As the public record indicates the DOJ [Department of Justice] has been actively investigating Mr Epstein and other targets for more than 16 years, yet the first time they requested the Duke's help was on 2nd January 2020.
"Importantly, the DOJ advised us that the Duke is not and has never been a 'target' of their criminal investigations into Epstein and that they sought his confidential, voluntary cooperation."
The statement describes the alleged course of discussions with the DOJ, claiming that their co-operation was to remain confidential.
"The Duke of York has on at least three occasions this year offered his assistance as a witness to the DOJ. Unfortunately, the DOJ has reacted to the first two offers by breaching their own confidentiality rules and claiming that the Duke has offered zero co-operation. In doing so, they are perhaps seeking publicity rather than accepting the assistance proffered," the statement read.
Prince Andrew's statement comes after a source reportedly claimed to The Sun that the Duke was moving "into the realms of a criminal investigation".
"The [Department of Justice] does not make a request of this nature lightly, especially one involving a senior member of the British royal family," the sourced claimed to the British publication.
In response to Andrew's latest statement, US attorney Geoffrey Berman responded by claiming the royal had declined the department's request for an interview.
The attorney explained: "If Prince Andrew is in fact serious about cooperating with the ongoing federal investigation, our doors remain open and we await word of when we should expect him."
In the interview with journalist Emily Maitlis, the Prince spoke of the accusations made against him by the woman.
"It didn't happen," Prince Andrew claimed.
"I can absolutely categorically tell you it never happened. I have no recollection of ever meeting this lady, none whatsoever."
In the interview, the Prince also relayed some claims, which came across as rather unusual to many, including that he had taken Princess Beatrice to a pizza restaurant around the time he had been accused of being out in London with the woman.
He also said her claims that he was profusely sweating could not be true, because he had a pre-existing medical condition that made it "almost impossible" to sweat.