An insider told RadarOnline.com: “George and Amal have been arguing over their varying lifestyles — and rumours of a rift have been going around for months."
The source continued: “She’s all business, he’s all play. They’re like oil and water. They don’t mix — and there’s talk of a possible custody fight over the twins.”
As well as George not being seen with his children in 200 days, Amal and her husband haven't been photographed together since August 2011, RadarOnline.com reports.
An insider told the publication: “Amal skipped George’s annual Halloween party for his Casamigos tequila in Las Vegas last year, and they spent their fourth wedding anniversary apart."
Insiders have revealed to RadarOnline.com that Amal has packed her bags and fled the marital home she shares with George in favour of living in an Italian hideaway.
It has been claimed by sources that Amal has retreated to the two-villa plot the pair purchased in an all-cash deal made on the down low and has taken toddlers Alexander and Ella with her.
Amal has also reportedly told George that if he were to come to the villa, he would have to stay in the guest house.