'I'm not great around big egos, that doesn't bring out the best in me,' she revealed.
The 59-year-old cohosted the Today show alongside Karl for for 10 years, before departing for Network 10.
Wilkinson also took the opportunity to praise her Network 10 colleagues, including Carrie Bickmore, Fifi Box, Amanda Keller, Julia Morris and Gorgi Coghlan.
'One of the absolute bonuses that I really hadn't anticipated in moving to Ten, is the calibre of my collages,' Lisa added.
The interview comes shortly after Wilkinson paid tribute to Karl after he was sacked from the Today show.
'Wishing @karlstefanovic_ all the best. Because when it was good, it was great @thetodayshow,' she wrote alongside a photo of the pair.