'It’s up to the people,' Graham told the Los Angeles Times. 'She would absolutely do it.'
Social media users were also quick to rally behind the idea of Winfrey running for President after her moving speech at the Globes.
While accepting the Cecil B. DeMille Award at the ceremony - an honorary award chosen by the Hollywood Foreign Press Association for outstanding contributions to the world of entertainment.
Meryl Street even promoted the idea, telling the Washington Post: 'She launched a rocket tonight. I want her to run for president. I don’t think she had any intention [of declaring]. But now she doesn’t have a choice.'
Celebrities and social media users started the trending hashtag #Oprah2020.
What do you think of the idea of Oprah Winfrey running for President? Head to our Facebook page to let us know.