The couple confirmed they were expecting their third child in February.
Bublé and Lopilato also share sons Noah, 4, and Elias, 2.
In 2016, the couple revealed in a statement that Noah had been diagnosed with cancer.
A statement from the pair read, 'We are devastated about the recent cancer diagnosis of our oldest son Noah who is currently undergoing treatment in the US.'
'Luisana and I have put our careers on hold in order to devote all our time and attention to helping Noah get well. At this difficult time, we ask only for your prayers and respect for our privacy. We have a long journey in front of us and hope that with the support of family, friends and fans around the world, we will win this battle, God willing.'
Later, the couple confirmed 'the worst was over'.
Congratulations to the growing family!