Meghan was offered the September cover, but declined to avoid taking attention from the causes she wants to support, according to Express.co.uk.
The collaboration with Vogue was allegedly encouraged by Meghan's close friend Amal Clooney, who urged her to promote her charity work on a larger platform.
The Los Angeles-born actress is in good company, with a number of the royal family appearing in British Vogue before her.
Meghan's sister-in-law Kate Middleton took the front cover in June 2016 with the tag line: "HRH The Duchess of Cambridge."
Her late mother-in-law Princess Diana graced the cover an impressive three times, as well as covering US Vogue in 1997 after her divorce from Prince Charles.
Queen Elizabeth's only daughter, Princess Anne, also appeared in three UK editions of Vogue between 1971 and 1973.
The news comes as the Duke and Duchess of Sussex continue to weather a storm of controversy sparked by their $4.3 million renovations to Frogmore Cottage, as well as their decision to hold Archie's christening in private at Windsor Castle with the identities of the child's godparents a closely guarded secret.
The official photos from Archie's christening, taken by royal photographer Chris Allerton, also caused a stir thanks to the Duchess of Cambridge's uncomfortable demeanour and Prince William's 'sour faced' smirk.
The release has done little to dispel rumours of a rift between the 'Fab Four', who professionally parted ways with the split of Prince William and Prince Harry's joint charity the Royal Foundation last month.
On June 26, the British High Commissioner to South Africa confirmed Prince Harry, Meghan and their son Archie Harrison will visit South Africa this autumn.
The royal couple's official social media account, Sussex Royal, announced the Duke will also conduct solo engagements in Angola, Malawi and Botswana, Harper's Bazaar reports.
Three days later, Kensington Palace announced the Duke and Duchess of Cambridge will visit Pakistan for a royal tour in autumn 2019.
It seems Prince Harry will continue the work of his mother, Princess Diana, who was a vocal supporter of landmine clearance efforts in Africa.
According to the Mirror, the Sussexes trip to Africa could see them say for extended periods - up to six months at a time, over a period of two to three years.
