According to The Daily Mail, the documentary "will offer an insight into the emotional journey the 'vulnerable and bruised' royal couple have been catapulted into since their wedding while following their ten-day tour of southern Africa."
What's more, Prince Harry appears to discuss leaving the UK to live in Africa in the documentary, which is titled Harry & Meghan: An African Journey.
"I don't know where we could live in Africa at the moment," the Duke of Sussex told Tom Bradby.
"We've just come from Cape Town, that would be an amazing place for us to be able to base ourselves, of course, it would.
"But with all the problems that are going on there, I just don't see how we would be able to really make as much difference as we'd want to."
Prince Harry - who shares son Archie with Meghan - says Africa will be his (along with Meghan's) main focus in the future.
"The rest of our lives, especially our life's work will be predominantly focused on Africa, on conservation.
"There are 19 commonwealth countries across this continent, there's a lot of things to be done, there's a lot of problems here but there's also huge potential for solutions."
Tom Bradby told the Sunday Times that he had asked the Duchess of Sussex whether she and Harry were able to cope with the mounting pressure of the media.
She replied "We are taking it one day at a time," before admitting that the couple is currently "existing, not living."
When Meghan admitted she was 'not really OK' in a preview clip on Friday, she was me with an overwhelming amount of support on Twitter.
According to The Daily Mail, #WeLoveYouMeghan became the top trending topic within an hour.
Tom Bradby also told the publication that "as the journey wore on, another human story gradually emerged, of a couple who clearly feel under the most extreme pressure and seem, at times, to be buckling beneath it."
He also noted that the Duke appeared to be "tired" and even "burn out."
Harry & Meghan: An African Journey will air at 9 pm on ITV.