The trip will be a special one for theDuke of Sussex, as South Africa was a place his late motherPrincess Dianavisited many times, with rumours suggesting that much of the trip will be following in the Princess of Wales footsteps.
WATCH: Meghan and Harry's Africa trip for UK business
We know that the Duke and Duchess of Sussex will begin their royal tour in South Africa, and Prince Harry will finish solo in Malawi and Angola, retracing his mother's footsteps.
The Royal will also briefly attend Botswana on a “short working visit”.
How Meghan and Harry's Royal tour of Africa will pay tribute to Princess Diana
Prince Harry's visit to Angola will be a special tribute to Princess Diana.
The Duke of Sussex is set to visit Huambo, the same place his mother was famously captured in the de-mining zone.
Princess of Wales wearing protective body armour and a visor visits a landmine minefield being cleared by the charity Halo in Huambo.
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Prince Harry has worked with the organisation that aims to de-mine the active zones in Africa before - The Halo Trust - visiting Mozambique in 2010.
Prince Harry is seen with a deminer from The HALO Trust, 2010.
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Meghan will also pay tribute to her husband's late mother by wearing a special piece of jewellery from Diana's collection.
Megan Markle is known for memorialising the Princess of Wales in such a way, being spotted wearing a beautiful pair of Diana's butterfly earrings while the Duke and Duchess of Sussex were on their Royal tour of Australia.
Duchess of Sussex greets members of the crowd at the Sydney Opera House on October 16, 2018.
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An official statement by Buckingham Palace already stated that the Sussex’s will commence their tour of South Africa, Botswana, Malawi and Angola on September 23, and will finish October 2.
Milly HaddrickMilly is a journalist who passionately devours all the latest and juiciest news. A devout tea enthusiast who's a firm believer in quality downtime, Milly's weekends are usually spent relaxing with a big plate of food, a nice cuppa and the crossword.