Meg Ryan’s look has shocked onlookers while attending the Liberty Theater as part of Advertising Week in New York on Tuesday.
Ryan’s complexion was wrinkle-free, with seemingly fuller lips.
Similarly, the actress made headlines after presenting at the Tony Awards in June.
‘I’m old enough to remember when Meg Ryan looked like Meg Ryan, one fan wrote on Twitter in June.
Another wrote: ‘Dear God.... What happened to Meg Ryan?’
Addressing plastic surgery rumors, Ryan told Porter magazine, 'We get stuck in these conversations about looks and hair color and our roots.
'It's interesting and funny for five minutes. But it's not that interesting.'
She said: 'I love my age. I love my life right now. I love the person I've become, the one I've evolved into.'