Viewers took to Twitter to comment on the 54-year-old’s new appearance as she introduced a performance by the cast of She Loves Me.
Ryan has previous discussed plastic surgery, insisting she doesn’t listen to rumours she's gone under the knife.
'I don’t pay a lot of attention frankly,' she said.
'There’s a lot of hatred in the world today, it’s so easy to judge. Imagine being a hater, how stupid! My women friends are not sitting around talking about … well, sometimes there are conversations like that, but the people I value talk about kids growing up, what kind of world they are going into, what we are eating, what we are breathing.'