Despite not attending the ceremony, the 26-year-old beat out other big name actresses including Scarlett Johansson, Tilda Swinton and Gal Gadot. The win came as a big shock to many - perhaps even to absent Margot - with the film widely labelled one of the year's worst dogs.
Suicide Squad was widely panned by critics with Margot’s performance one of the only redeeming parts of the film.
In other exciting news for the actress, Margot is slated for her own standalone Harley Quinn movie as part of the ongoing DC Comics Universe.
The former Neighbours star also recently made headlines when she moved from London, where she had been living since 2014, to Los Angeles with partner of 3 years, Tom Ackerly.