Snake handler Arslan Valeev asked viewers to contact his ex-wife Ekaterina 'Katya' Pyatzhkina after showing them what appeared to be a bite wound on his hand.
The 31-year-old blogger, who ran YouTube channel BobCat TV with his former partner, visibly deteriorated on camera before walking off-screen where he collapsed.
At least one viewer is known to have called emergency services, which later arrived but were unable to save him.
In the live stream, his breathing becomes more rapid and his eyes begin to roll into the back of his head.
He tells the audience, 'Pass on to Katya that I love her very much,' before moving his hand towards the camera.
He continues, 'Beautiful, isn't it? Oh, damn, how it...Bye to everyone...I can't believe it is happening to me...'
Earlier this month, Arslan, who is from St Petersburg in Russia, publicly apologised after he allegedly beat Katya so badly she suffered a concussion.