While Russian-born supermodel Irina watched from the audience with Bradley's mother, some believed the writing was on the wall for their four year relationship.
The exes are parents to two-year-old daughter Lea De Seine.
Yesterday, pop culture fans couldn't believe their eyes when Gaga's ex-fiancé Christian liked Irina Shayk's latest Instagram photo, a sexy shot showing the Victoria's Secret model wearing nothing but a derriere-baring black body suit beside a waterfall in Iceland.
According to People, Irina jetted to Iceland after news broke of her split from Bradley.
Sources told the publication the ultra-private couple had "drifted apart" when "emotionally absent" Bradley was directing A Star is Born and had been "living totally separate lives" for a long time.
"If he was in Los Angeles, she's out of town, and if she was in town, he was out of town," the insider revealed.
Meanwhile, Gaga is busy with her Las Vegas residency which kicked off earlier this month.
Of her rumoured romance with Cooper, the Born This Way hitmaker continues to flatly deny anything more than a solid friendship between the stars.
In a recent interview with Jimmy Kimmel, Gaga bluntly replied "no" when asked if she was having an affair with Bradley.