A good friend of both the Duke and Duchess of Sussex, the 64-year-old says she has something very special in mind for the newborn.
Chatting to Access Hollywood, Oprah said: "I have a standard gift that I do for people that I really care about. So I don't know the baby's name or the baby's gender, but this baby will have enough books to last a lifetime!"
The TV personality recently joined forces with soon-to-be dad Harry for a new project focussed on mental health.
Royal baby: What do we know so far?
We're excited to be exploring it together - he's a true partner" Oprah told E News! of the duo's collaboration.
"Every week we do a weekly update letting him know where we are, directors we've spoken to, how many people we're planning on bringing on board and what we're thinking of naming it.
"He weighs in.
"He always has something to say about everything."